La codeina viene utilizzata for each contrastare il dolore di intensità lieve o moderata. In combinazione con altri farmaci viene inoltre impiegato per calmare la tosse.
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chloroquine will improve the stage or effect of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Helps prevent conversion of codeine to its Lively metabolite morphine.
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Steer clear of using codeine in adolescents 12 to eighteen many years of age who have other danger aspects that could boost their sensitivity to respiratory depressant results of codeine; hazard things involve conditions affiliated with hypoventilation, which include postoperative standing, obstructive rest apnea, being overweight, extreme pulmonary ailment, neuromuscular ailment, and concomitant utilization of other drugs that result in respiratory melancholy.
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This conclusion not only addresses issues about the misuse and addictive likely of codeine linctus but will also underscores the importance of prioritising affected individual click here well-getting.
The codeine might enhance frequency of seizures in individuals with seizure Conditions, and should maximize risk of seizures occurring in other medical configurations linked to seizures; watch sufferers by using a record of more info seizure Issues for worsened seizure Command in the course of therapy
Codeine is contraindicated in patients who are regarded to become ultrafast CYP2D6 metabolisers: Codeine is transformed in its Lively metabolite morphine through the Makatussin Syrop hepatic isoenzymes CYP2D6, several of which exist with read more genetic polymorphisms.
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